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DMT (N,N-Dimethyltryptamine) is a hallucinogenic tryptamine drug that occurs naturally in many plants and animals. It is also referred to as the “spirit molecule” due to the intense psychedelic experience. Although lesser known than other psychedelics such as LSD or magic mushrooms, DMT produces a brief but intense visual and auditory hallucinogenic experience.Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen in South America. Slang terms include Five-methoxy, The power, and Toad venom
The drug has been used for centuries in South America and the Caribbean. To this day, it is used by indigenous groups in the form of intranasal snuffs.
It can produce fully dissociative psychedelic experiences, similar to DMT. However, 5-MeO-DMT is far less visual with its effects and seems more likely to cause terror/anxiety responses.
5-MeO-DMT = 5-MeO; 5-methoxy-N,N-dimethyltryptamine; N,N-Dimethyl-5-methoxytryptamine; 5-Methoxy-N,N-dimethyltryptamine; Methoxybufotenin.
Dimethyltryptamine (DMT) is an intense naturally-occurring psychedelic that’s also found endogenously in the human body. It’s not as popular as LSD or psilocybin, though its use has grown over time.
DMT is typically inactive orally. This changes when it is combined with an MAOI. An example of this combination is ayahuasca, which contains Banisteriopsis caapi (MAOIs) and Psychotria viridis (DMT).
An analysis of 16 ayahuasca preparations found the following concentrations per 100 mL:
The concentrations in ayahuasca can vary significantly.
How do you take DMT?
DMT can be taken in many forms, but most typically it is either taken in the ayahuasca brew or smoked as a powder. You can read a detailed guide to smoking it here. The powder form will produce a short-lasting but intense trip, and the ayahuasca brew will produce a long-lasting experience.
Is DMT safe?
On its own, DMT is quite safe to ingest in reasonable dosages. Any potential risks come from interaction with other substances or taking it in an unsuitable setting.
Can I microdose with DMT?
There is not much information about DMT microdosing, as microdosing is most commonly performed with LSD and psilocybin. However, because DMT is a classic psychedelic in the same family as LSD and psilocybin, it can be microdosed in a similar way. Check out our detailed guide on microdosing DMT for more information.
How long does DMT last?
The effects of DMT last about 5-30 minutes when smoked. If taken in the ayahuasca form, the experience can last anywhere between two and 15 hours, with four to six hours being the average duration for most people.
Can DMT give me a bad trip?
Like most psychedelics, DMT is a very powerful drug and has the potential to be very unpleasant if not treated with respect. Follow the 6S’s of psychedelic use to minimize the risks of a bad experience. Start with a low dose if it’s your first time.
Will I always achieve a breakthrough?
Not necessarily, especially if taken as an ayahuasca brew. However, DMT is a powerful psychedelic. When smoked, it is likely to produce out-of-body experiences and extreme changes in perception.
Is DMT produced naturally in the body?
This is an area of some controversy, but there is evidence to suggest that DMT is present in animal physiology.