25I-NBOMe is a substituted phenethylamine, a synthetic derivative of the classical hallucinogen 2C-I which was subject to a risk assessment at European level in 2003. Apart from its use as an analytical reference standard and its use in scientific research, radiolabelled 25I-NBOMe has been used to study the serotonergic system in the brain. 25I-NBOMe has no known legitimate uses as an industrial, cosmetic or medicinal compound.when it was first sold by vendors specializing in the supply of designer drugs
The “25I” component within 25I-NBOMe refers to the location of the iodine atom on the phenethylamine nucleus. The “NBOMe” component refers to the N-(2-methoxybenzyl) part of the molecule. There are a number of other “NBOMe” derivatives that have been notified to the Early Warning System. These include: 25B-NBOMe, 25C-NBOMe, 25H-NBOMe, 25E-NBOMe, 25N-NBOMe, 25D-NBOMe, 25iP-NBOMe, 25G-NBOMe, 25B-N(BOMe)2, 25I-NBMD, C30-NBOMe, and RH-34. buy 25i nbome online.25I–nbome, n-bomb, smiles. NBOMe is a potent group of synthetic hallucinogenic drugs that mimic LSD.25I–NBOMe, 25C-NBOMe, and 25B-NBOMe are three synthetic substances.Within this group, 25I–NBOMe is an outstanding substance with powerful effects and high affinity with the serotonin 2a (5HT2a) receptor.For 25I–NBOMe, 25-I is a common abbreviation for 25I–NBOMe, which is a (n-
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induces a head-twitch response in mice which is blocked completely by a selective 5-HT2A antagonist, suggesting its psychedelic effects are mediated by 5-HT2A.N-Bomb is a powerful hallucinogen, which means it changes the way you see objects and reality
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In recent years, N-methoxybenzyl-methoxyphenylethylamine (NBOMe) derivatives, a class of designer hallucinogenic drugs, have become popular drugs of abuse. These drugs have been the cause of severe intoxications and even deaths. They act as 5-HT2A receptors agonists and have been reported to produce serotonin-like syndrome with bizarre behavior, severe agitation and seizures persisting for as long as 3 days. The most commonly reported derivatives are 25I-NBOMe, 25B-NBOMe and 25C-NBOMe, respectively 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl) methyl]ethanamine, N-(2-methoxybenzyl)-2,5-dimethoxy-4-bromophenethylamine and N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine. Like many low dose hallucinogenic drugs these compounds are often sold on blotter paper. Three different types of commercially available blotter papers reported to contain NBOMe derivatives were obtained. These blotter papers were screened using Direct Analysis in Real Time AccuTOFTM mass spectrometry followed by confirmation and quantification by high-performance liquid chromatography triple quadrapole mass spectrometry. The major drug present on each of the three blotter products was different, 25I-NBOMe, 25C-NBOMe or 25B-NBOMe. The blotter papers were also found to have minute amounts of two or three NBOMe derivative impurities of 25H-NBOMe, 25I-NBOMe, 25C-NBOMe, 25B-NBOMe and/or 25D-NBOMe.
Recently, a new class of “2C” serotonin 5-HT2A receptor agonists designer drugs, dimethoxyphenyl-N-[(2-methoxyphenyl) methyl]ethanamine (NBOMe) derivatives have become easily obtainable over the Internet which has resulted in their abuse in the USA, Europe and Asia (1). Stimulation of 5-HT2A receptors is responsible for the hallucinogenic effects of recreational drugs such as lysergic acid diethylamide (LSD) and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (2). The terminology “2C” is an acronym coined by Alexander Shulgin for the two carbon atoms between the benzene ring and the amino group on the perceptional distorting and/or hallucinogenic phenylethylamine derivatives he synthesized (3, 4). Several of these derivatives, including 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl) methyl]ethanamine (25I-NBOMe) and N-(2-methoxybenzyl)-2,5-dimethoxy-4-bromophenethylamine (25B-NBOMe) were first synthesized by Ralf Heim at the Free University of Berlin as part of a series of pharmacological tools to study the 5-HT2A receptor (5–7). Blotter papers containing 25I-NBOMe appeared on the designer drug market beginning in 2011 (8) and since then numerous NBOMe derivatives have been identified in blotter papers seized from the illicit drug market including: 2-(2,5-dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine (25D-NBOMe), 2-(4-ethyl-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25E-NBOMe), 2-(2,5-dimethoxy-3,4 dimethylphenyl)-N-(2-methoxybenzyl)ethanamine (25G-NBOMe), N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine (25C-NBOMe) and 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2,3-methylenedioxyphenyl) methyl]ethanamine (25I-NBMD)
2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe) is a synthetic derivative of the classical hallucinogen 2-(4-iodo-2,5-dimethoxyphenyl)ethanamine, also known as 4-iodo-2,5-dimethoxyphenethylamine or 2C-I
What are the effects of 25i-NBOMe? and Pharmacology of NBOMes
In vitro studies indicated that NBOMe compounds are ultrapotent and highly efficacious agonists of 5-HT2A and 5-HT2C receptors (Ki values in low nanomolar range), with more than 1000-fold selectivity for 5-HT2A compared with 5-HT1A. The compounds display higher affinity for 5-HT2A receptors than their 2C counterparts and have markedly lower affinity, potency, and efficacy at the 5-HT2B receptor than at 5-HT2A or 5-HT2C. In addition, NBOMes have a significant affinity (Ki < 300 nM) for adrenergic α1 receptors but not so H1-histamine, dopamine D1, D2, and D3 receptors or the monoamine transporters DAT, NET, or SERT. Molecular modeling and molecular dynamics simulation studies performed on a human 5-HT2A receptor model identified several amino acid residues as putative binding sites of NBOMes. It is suggested that the binding pocket, localized among transmembranes.
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